Diosmin is a semisynthetic flavonoid molecule derived from citrus d (modified hesperidin).It is an oral phlebotropic drug used in the treatment of venous disease, i.e., chronic venous insufficiency (CVI) including spider and varicose veins, leg swelling (edema), stasis dermatitis and venous ulcers. It is also used as a stand-alone or surgical adjunctive therapy in hemorrhoidal disease (HD).
The product is used for treating various disorders of blood vessels including hemorrhoids, varicose veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage) in the eye or gums. It is also used to treat swelling of the arms (lymphedema) following breast cancer surgery, and to protect against liver toxicity. It is often taken in combination with hesperidin.
There are extensive clinical trials that show diosmin improves all stages of venous disease including venous ulcers and improves quality of life. There are no prospective studies in arterial disease.
Diosmin is currently a prescription medication in some European countries (under the Dio-PP, Venotec, Daflon etc. tradenames), and is sold as a nutritional supplement in the United States.
Diosmin has been found to be effective in mitigating hyperglycemia in diabetic rats. It is also speculated that it might have potential in the treatment of neurodegenerative diseases, such as Alzheimer’s disease.
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Diosmin prolongs the vasoconstrictor effect of norepinephrine on the vein wall, increasing venous tone, and therefore reducing venous capacitance, distensibility, and stasis. This increases the venous return and reduces venous hyperpressure present in patients suffering from CVI.
Diosmin improves lymphatic drainage by increasing the frequency and intensity of lymphatic contractions, and by increasing the total number of functional lymphatic capillaries. Furthermore, with hesperidine, it can decrease the diameter of lymphatic capillaries and the intralymphatic pressure.
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