Hesperetin is one of the Citrus bioflavonoid. It is solid substance, light-brown crystalline powder, poorly soluble in water. it belongs to the flavanone class of flavonoids. Hesperetin, in the form of its glycoside hesperidin, is the predominant flavonoid in lemons and oranges. it is a bioflavonoid and, to be more specific, a flavanone. Hesperidin (a flavonone glycoside) is water-soluble due to the presence of the sugar part in its structure, so on ingestion it releases its aglycone, i.e, Hesperetin. It is found in Citrus fruits.
It is a cholesterol lowering flavanoid found in a number of citrus juices. It appears to reduce cholesteryl ester mass and inhibit apoB secretion by up to 80%. It may have antioxidant, anti-inflammatory, anti-allergic, hypolipidemic,vasoprotective and anticarcinogenic actions.
Mechanism of Action
It reduces or inhibits the activity of acyl-coenzyme A:cholesterol acyltransferase genes (ACAT1 and ACAT2) and it reduces microsomal triglyceride transfer protein (MTP) activity. Hesperetin also seems to upregulate the LDL receptor. This leads to the reduced assembly and secretion of apoB-containing lipoproteins and enhanced reuptake of those lipoproteins, thereby lowering cholesterol levels.
It has properties of antioxidant,anti-inflammatory, anti-allergic, hypolipidemic,and anticarcinogenic actions. Hesperidin can also act as a vasodilator, which may be useful in Hypertension.
It is also used in functional food or dietary supplement as its properties. More studyings are in process to enlarge its use in more industries.
It is known to has anti-esterlysis function, it can inhibit tumor from promoting; as 3 gamma – hydroxyl steroidal dehydrogenase inhibit preparation, high activate aspirin, weak aldose reductase inhibitors, promote rat liver cells DNA synthetic in vitro, pick up a certain antibacterial and antiviral activity, can be used as plant growth promoters.
Commercial Hesperetin can be obtained by hydrolyzation from Hesperidin (extracted from immature citrus fruit).
Di’ao Pharma supply high quality Hesperetin.